Table 4.

Importance of Harms Related to Individual Testing Results

	Clinicians (n=104)	Patient Stakeholders (n=104)	P-value
1: How harmful would it be if testing suggests someone has Alzheimer disease when they do not? (This is called a “false positive” diagnosis.)	8 (IQR 7–9) Range 4–9	8 (IQR 7–9) Range 1–9	0.952
2: How harmful would it be if testing suggests someone does not have Alzheimer disease when they do? (This is called a “false negative” diagnosis.)	7 (IQR 6–8) Range 1–9	8 (IQR 7–9) Range 1–9	0.001
3: How harmful would it be if a test suggests someone will develop Alzheimer disease dementia within the next 3 years but they do not?	8 (IQR 7–9) Range 1–9	7 (IQR 7–8) Range 1–9	0.001
4: How harmful would it be if a test is positive for Alzheimer disease and doctors stop looking for other possible explanations for a patient’s problems?	7 (IQR 5–8) Range 1–9	8 (IQR 6–9) Range 3–9	<0.001
5. How harmful is depression resulting from receiving a correct Alzheimer disease diagnosis?	6 (IQR 4–7) Range 1–9	7 (IQR 6–9) Range 1–9	<0.001
6: How harmful is suicide or a suicide attempt due to receiving a correct Alzheimer disease diagnosis?	9 (IQR 7–9) Range 1–9	9 (IQR 7–9) Range 1–9	0.751
7: How harmful is discrimination based on the diagnosis of Alzheimer disease?	8 (IQR 7–9) Range 1–9	8 (IQR 7–9) Range 1–9	0.366
8: How harmful is an inability to get long-term care insurance due to a diagnosis of Alzheimer disease?	8 (IQR 7–9)* Range 1–9	8 (IQR 7–9) Range 1–9	0.688
9: How harmful is the loss of job/volunteer opportunities due to a diagnosis of Alzheimer disease?	8 (IQR 6–9) Range 1–9	8 (IQR 6–9) Range 1–9	0.505
10. How harmful is the loss of driving due to a diagnosis of Alzheimer disease?	6 (IQR 5–8) Range 1–9	8 (IQR 6–9) Range 1–9	0.006

Responses: A little harmful (limited importance) 1–3, harmful (important) 4–6, extremely harmful (critical importance 7–9). Data presented as median (interquartile range, IQR).

^*n=103 for this question