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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Toxicology. 2019 Jul 19;425:152248. doi: 10.1016/j.tox.2019.152248

Fig. 4.

Fig. 4.

Fig. 4.

The protection of curcumin against MeHg-induced toxicity in primary rat astrocytes independently of PKCδ. (A) Effects of curcumin on the expression of PKCδ. (B) Effect of Ro 31–8220 and rottlerin on the expression of PKCδ. *P < 0.05 vs. control group. (C, D) Effect of co-treatment with Ro 31–8220 or rottlerin and curcumin (5 μM, 12 h) on the expression of Nrf2, HO-1 and NQO1. *P < 0.05 vs. Blank control group. N.S. (P > 0.05) vs. curcumin alone group. (E, F) Effect of Ro 31–8220 or rottlerin on the protective effects of curcumin against MeHg-induced astrocyte death. *P < 0.05 vs. control group, #P < 0.05 vs. MeHg alone treatment group. N.S. (P > 0.05) vs. Cur+MeHg treatment group. Data are expressed as mean ± SD of at least three independent experiments. Cur, curcumin; MeHg, methylmercury. N.S., not significant.