Table 3.

Distribution of methylation levels in 30 genes by p,p’-DDE exposure of daughters in the Child Health and Development Studies Pregnancy Cohort

	p,p’-DDE ≤35.23, μg/L		p,p’-DDE :35.23–58.49, μg/L		p,p’-DDE >58.49, μg/L
Gene	Median, %	IQR	Median, %	IQR	Median, %	IQR	P.value
ADRB1	23.5	9.3	24.3	8.6	26.5	9.8	0.14
ARHGEF7	44.0	9.5	45.9	8.9	44.5	9.1	0.29
BRCA1	80.7	14.0	82.4	10.2	82.9	11.3	0.30
CCDC85A	34.7	7.7	34.2	8.2	36.4	8.4	0.02
CCNL1	0.3	0.8	0.3	0.8	0.2	0.6	0.49
CDH1	7.3	2.0	7.3	2.6	7.7	3.0	0.19
CELF4	55.7	11.1	57.3	11.3	55.7	13.1	0.54
chr11	7.7	3.9	8.5	5.2	8.2	5.2	0.32
chr12	78.7	4.6	78.1	5.1	78.2	5.2	0.32
chr16	81.6	5.4	82.0	6.4	82.1	6.3	0.21
chr4	82.3	8.0	81.4	8.4	80.9	9.8	0.36
CYP1A1	50.0	20.1	51.8	17.3	55.0	19.2	0.03
DLGAP2	97.2	1.1	96.9	1.2	97.1	1.0	0.17
ESR1	55.1	19.6	55.0	20.6	56.0	23.7	0.88
GAB2	96.9	2.4	97.2	2.7	97.0	3.4	0.70
GNA12	37.9	21.1	35.7	21.4	39.7	32.4	0.63
IGF1	82.2	4.3	83.2	7.4	84.5	6.6	0.23
MCHR2	13.4	3.5	12.2	3.9	13.8	3.9	0.07
OBSCN	92.5	1.7	92.5	2.1	92.2	1.7	0.25
PCDHGB1	40.6	7.8	40.3	8.0	39.9	9.1	0.73
PEX14	67.0	7.1	65.8	7.5	67.5	8.9	0.25
RAD51L1	98.1	1.5	98.1	1.7	98.0	1.9	0.97
RECQL4	86.7	4.6	86.8	4.5	87.5	3.6	0.16
SLC39A14	87.3	9.7	87.3	10.0	87.2	10.9	0.25
SLC6A3	73.6	4.9	74.5	6.0	74.1	5.5	0.72
TCF7L2	52.3	13.5	50.3	13.9	54.5	16.6	0.23
TERT	96.8	2.7	96.6	2.9	97.1	2.5	0.50
XRCC3	79.6	3.6	79.9	3.2	79.7	3.3	0.94
ZFPM2	44.2	11.4	44.5	11.9	44.6	10.9	0.59
ZNF483	35.9	3.4	36.0	3.4	35.4	4.0	0.86

p value of Kruskal-Wallis test

IQR: The interquartile range