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. Author manuscript; available in PMC: 2019 Aug 27.
Published in final edited form as: Adv Exp Med Biol. 2019;1115:167–190. doi: 10.1007/978-3-030-04278-3_8

Figure 3: Simplified scheme for lipid-dependent gating.

Figure 3:

A VSD (blue bars with + charges in red) flanking a pore domain (green cylinder) switches between resting (“down” state of the VSDs) and activated (“up” state of the VSDs) state in Group II and Group I lipids at ΔV=0, showing the inner and outer crevices of the gating pore. The pore is assumed to take an inward-facing conformation in the resting state and an out-ward-facing conformation in the activated state.