Skip to main content
. Author manuscript; available in PMC: 2019 Aug 27.
Published in final edited form as: Adv Exp Med Biol. 2019;1115:167–190. doi: 10.1007/978-3-030-04278-3_8

Figure 5: A gating model for CHOL-dependent gating.

Figure 5:

The fully resting state (C0) switches to C1 states in four independent steps because of four VSDs. The concerted coupling between four VSDs leads to the closed state immediately before the channel opening (Cx). The open state (O) can become inactivated (I) so as the closed state (Cx as an example). Cholesterol as the ligand (L) can be partitioned around channels in each state. The measured activation rate [kon(V)] will be determined by the forward rate-limiting step. The deactivation rate [koff(V)] will be determined by the closing rate of O.