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. Author manuscript; available in PMC: 2019 Aug 27.
Published in final edited form as: Adv Exp Med Biol. 2019;1115:167–190. doi: 10.1007/978-3-030-04278-3_8

Figure 6: CHOL inhibits KvAP in bSUMs.

Figure 6:

A) Activity of KvAP in bSUMs made of PE:PG (3:1), pulsed from −160 to 180mV at 10 mV steps. B) Recordings from KvAP channels in bSUMs made of DOPC with 9.6 mol% of CHOL. C) G-V for KvAP in bSUMs of DOPC (blue; n=3), PE:PG (3:1, black; n=4), DOPC/CHOL (4.0 mol% in red and 9.6% in brown; n=3) and PE/PG 3:1 BLMs (grey; n=3). Boltzmann fittings (solid lines) yielded (Zδ, V1/2) (e0, mV) for channels in BLM (3.0, −47.5), PE/PG bSUMs (2.0,−45), DOPC bSUMs (1.6, −42.0), 4.0 mol% CHOL (1.6, 118) and 9.6 mol% CHOL (2.0,162) in DOPC bSUMs. Error bars: s.d.