Table 1.
Unsolved mutants for anophthalmia/microphthalmia and microphthalmia/cataract
| Gene symbol | Anophthalmia/microphthalmia | Microphthalmia/cataract | Strain available (if and where) |
|---|---|---|---|
| Alm | Anterior lenticonus with microphthalmia | Extinct | |
| B2b1511 | Anophthalmia, microphthalmia | JAX | |
| B2b1702 | Anophthalmia, microphthalmia | Extinct | |
| B2b1963 | Anophthalmia, microphthalmia | JAX | |
| B2b2012 | Cyclops, anophthalmia, microphthalmia | Extinct | |
| B2b2110 | Anophthalmia, microphthalmia | JAX | |
| B2b2153 | Enophthalmia, anophthalmia, microphthalmia | JAX | |
| B2b2739 | Anophthalmia, microphthalmia | JAX | |
| bh | Brain hernia | Brain hernia | Extinct |
| Bld | Blind | Extinct | |
| Cat3 | Cataract 3 | HMGU | |
| dblr | Doubleridge | Extinct | |
| dcm | Dense cataract and microphthalmia | Extinct | |
| eob | Eye lids open at birth | Extinct | |
| exma | Exencephaly with severe microphthalmia/anophthalmia | Extinct | |
| ey2 | Eyeless 2 | Extinct | |
| ey3 | Eyeless 3 | JAX | |
| ey4 | Eyeless 4 | JAX | |
| eyl2 | Eyeless 2 Jackson | JAX | |
| Iac | Iris anomaly with cataract | Extinct | |
| Idc | Iris dysplasia with cataract | Extinct | |
| jrc | Juvenile recessive cataract | Extinct | |
| Lcl | Lens cloudy | Harwell, EMMA | |
| lg | Lid gap | Lid gap | Extinct |
| nmf131 | Cataract, microphthalmia | JAX | |
| Pcs | Polar cataract and small eyes | Extinct | |
| Rgsc258 | Cataract, microphthalmia | RIKEN | |
| Rgsc152 | Cataract, microphthalmia | RIKEN | |
| Rgsc1371 | Cataract, microphthalmia | RIKEN | |
| Rgsc1465 | Cataract, microphthalmia | RIKEN | |
| Tcm | Total cataract with microphthalmia | Extinct | |
| tirs | Tiresias | Extinct |
Data are from the Mammalian Phenotype Ontology Associations of the Mouse Genome Informatics database (http://www.informatics.jax.org/vocab/mp_ontology) using the search terms “anophthalmia”, “microphthalmia” and “cataract” (Sept. 25, 2018)
Resources for mouse mutants:
EMMA The European Mouse Mutant Archive; c/o Helmholtz Center Munich, Institute of Experimental Genetics; Neuherberg/Germany; https://www.infrafrontier.eu/search
HMGU Helmholtz Center Munich, Institute of Developmental Genetics; Neuherberg/Germany; http://www.helmholtz-muenchen.de/en/idg/research/neuropsychiatric-diseases/eye-disease/research/index.html
JAX The Jackson Laboratory, Bar Harbor, USA; https://www.jax.org/orderform
RIKEN Riken BioResource Research Center, Tsukuba/Japan; http://mus.brc.riken.jp/en/order
Harwell MRC Harwell; Harwell Science and Innovation Campus, Harwell/UK; http://www.mousebook.org/stock-list