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. 2019 Aug 26;9:12347. doi: 10.1038/s41598-019-48720-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Phenotypic examples of actives in A. ceylanicum E2L screen (A–C), C. elegans E2A screen (D–F), C. elegans L4-Adult screen (G–I) and A. ceylanicum xL3i screen (J,K). (A,D,G,J) Showing DMSO control with healthy nematodes, including normal morphology (all), development (A,D), and fecundity (G). Motility was also normal in all wells. (B,C,E,F,H,I,K) Examples of actives with arrested or stunted growth (B,C,E,F), dead C. elegans L4/adults (H), sterile C. elegans (I), or dead/paralyzed xL3i’s (K).