Table 2.
The total number of T. muris actives out of 32 drugs active against A. ceylanicum adults
T. muris adults 100 µM | A. ceylanicum E2L 30 µM | C. elegans L4 30 µM | C. elegans E2A 30 µM | |
---|---|---|---|---|
Total Actives | 19 | 21 | 12 | 6 |
Whipworms overlapping actives | . | 16 | 8 | 6 |
Whipworms missed actives | . | 3 | 11 | 13 |
. Each model tested was reevaluated for its ability to detect those drugs that affect whipworms adults. Out of the 32 hookworm standard actives, 19 showed activity against whipworms. Among all model tested E2L showed the highest number of overlapping actives (16 out of 19) with adult whipworms, compared to 8 and 6 in C. elegans L4 and E2A.