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. 2019 Aug 26;9:12359. doi: 10.1038/s41598-019-48821-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of the glycoforms in the proteins used in this study. (A) Schematic representation of the glycoforms present in fucosylated AFP, afucosylated AFP, and ALP. (B) Schematic representation of the glycoforms present in AFP produced by wild-type and FUT8^−/− HepG2 cells. Blue squares, green circles, yellow circles, yellow squares, magenta diamonds, and red triangles correspond to N-acetylglucosamine, mannose, galactose, N-acetylgalactosamine, sialic acid, and fucose, respectively.