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. 2019 Aug 26;9:12351. doi: 10.1038/s41598-019-48910-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PVS number (counted by experts readers) in centrum semi-ovale and basal ganglia across the analyzed subjects (N = 99), counted in T2-weighted (T2w) and enhanced PVS contrast (EPC) images. First row refers to the first expert reader, and second row relates to the second expert reader. (a,c) plots show the correlation between the number of PVS counted on T2w and EPC images, and their distribution. (b,d) bars compare the mean and standard deviation of PVS across all subjects as derived from T2w and EPC images. (e–h) plots are similar to (a–d) but related to basal ganglia scores. Note that expert readers counted significantly higher number of PVS when EPC was used (see results section for statistics).