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. 2019 Aug 26;9:12369. doi: 10.1038/s41598-019-48916-5

Table 3.

16 CpGs with DNA methylation levels in cord blood associated with BPA concentrations with FDR q < 0.05 in analysis for female infants.

CpG Chr Position Gene Relation to gens Relation to island Sapporo Taiwana Replicated for the direction
Female infantsb All newbornsc All newborns
Coefd p-value Coefd p-value Coefd p-value
cg12061021 1 95699574 RWDD3 TSS200 shore −0.006 6.55E-07 −0.004 0.000 −0.001 0.732
cg21461470 1 149821425 HIST2H2AA4 TSS1500 shore −0.010 1.01E-06 −0.006 0.001 0.000 0.948
cg22927302 3 50304463 SEMA3B TSS1500 open sea −0.015 4.00E-09 −0.005 0.014 NA NA
cg23603782 4 173884384 GALNTL6 Body open sea −0.010 1.81E-07 −0.006 0.000 −0.001 0.639
cg27629673 5 7462856 ADCY2 Body open sea −0.013 1.27E-07 −0.005 0.029 −0.000 0.905
cg22465281 5 65017296 NLN TSS1500 shore −0.014 1.36E-06 −0.005 0.036 NA NA
cg19734222 7 142020183 PRSS58 IGR open sea −0.030 1.25E-06 −0.011 0.030 0.002 0.734
cg11820931 10 70717302 DDX21 Body shore −0.013 1.23E-06 −0.009 1.00E-05 −0.005 0.354
cg08710564 11 8829438 ST5 5′UTR open sea −0.007 1.45E-06 −0.005 1.24E-06 −0.001 0.363
cg17339927 12 132991124 FBRSL1 IGR shore −0.014 1.63E-06 −0.007 0.006 −0.004 0.249
cg15193473 13 103453215 BIVM 5′UTR island −0.006 4.53E-07 −0.003 0.000 0.001 0.467
cg27624753 16 1673702 CRAMP1L Body shelf −0.007 1.10E-06 −0.005 6.65E-05 −0.004 0.097
cg27638035 18 35015753 BRUNOL4 Body open sea −0.011 2.68E-07 −0.004 0.049 −0.002 0.341
cg03636183 19 17000585 F2RL3 Body shore −0.016 2.81E-07 −0.005 0.067 −0.003 0.385
cg07964219 21 46847898 COL18A1 Body shore −0.009 3.90E-07 −0.005 0.008 0.000 0.990
cg15477600 22 21996253 SDF2L1 TSS1500 island −0.002 1.57E-06 −0.001 0.004 −0.000 0.691

aLinear regression analyses adjusted for the sex of child were applied to determine the associations of DNA methylation levels with ln-transformed BPA levels in the Taiwan cohort.

bAdjusted for maternal age, maternal educational levels, maternal pre-pregnancy BMI, maternal smoking during pregnancy, gestational age, and cord blood cell estimates.

cAdjusted for maternal age, maternal educational levels, maternal pre-pregnancy BMI, maternal smoking during pregnancy, gestational age, infant sex, and cord blood cell estimates.

dPartial regression coefficient indicates absolute DNA methylation change per ln-unit increase in BPA concentration.

Chr, chromosome; TSS, transcription start site; TSS200, 200 bases from TSS; TSS1500, 1500 bases from TSS; Body; gene body; UTR, untranslated region; NA, not available.