Table 3.
CpG | Chr | Position | Gene | Relation to gens | Relation to island | Sapporo | Taiwana | Replicated for the direction | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Female infantsb | All newbornsc | All newborns | ||||||||||
Coefd | p-value | Coefd | p-value | Coefd | p-value | |||||||
cg12061021 | 1 | 95699574 | RWDD3 | TSS200 | shore | −0.006 | 6.55E-07 | −0.004 | 0.000 | −0.001 | 0.732 | ✓ |
cg21461470 | 1 | 149821425 | HIST2H2AA4 | TSS1500 | shore | −0.010 | 1.01E-06 | −0.006 | 0.001 | 0.000 | 0.948 | |
cg22927302 | 3 | 50304463 | SEMA3B | TSS1500 | open sea | −0.015 | 4.00E-09 | −0.005 | 0.014 | NA | NA | |
cg23603782 | 4 | 173884384 | GALNTL6 | Body | open sea | −0.010 | 1.81E-07 | −0.006 | 0.000 | −0.001 | 0.639 | ✓ |
cg27629673 | 5 | 7462856 | ADCY2 | Body | open sea | −0.013 | 1.27E-07 | −0.005 | 0.029 | −0.000 | 0.905 | ✓ |
cg22465281 | 5 | 65017296 | NLN | TSS1500 | shore | −0.014 | 1.36E-06 | −0.005 | 0.036 | NA | NA | |
cg19734222 | 7 | 142020183 | PRSS58 | IGR | open sea | −0.030 | 1.25E-06 | −0.011 | 0.030 | 0.002 | 0.734 | |
cg11820931 | 10 | 70717302 | DDX21 | Body | shore | −0.013 | 1.23E-06 | −0.009 | 1.00E-05 | −0.005 | 0.354 | ✓ |
cg08710564 | 11 | 8829438 | ST5 | 5′UTR | open sea | −0.007 | 1.45E-06 | −0.005 | 1.24E-06 | −0.001 | 0.363 | ✓ |
cg17339927 | 12 | 132991124 | FBRSL1 | IGR | shore | −0.014 | 1.63E-06 | −0.007 | 0.006 | −0.004 | 0.249 | ✓ |
cg15193473 | 13 | 103453215 | BIVM | 5′UTR | island | −0.006 | 4.53E-07 | −0.003 | 0.000 | 0.001 | 0.467 | |
cg27624753 | 16 | 1673702 | CRAMP1L | Body | shelf | −0.007 | 1.10E-06 | −0.005 | 6.65E-05 | −0.004 | 0.097 | ✓ |
cg27638035 | 18 | 35015753 | BRUNOL4 | Body | open sea | −0.011 | 2.68E-07 | −0.004 | 0.049 | −0.002 | 0.341 | ✓ |
cg03636183 | 19 | 17000585 | F2RL3 | Body | shore | −0.016 | 2.81E-07 | −0.005 | 0.067 | −0.003 | 0.385 | ✓ |
cg07964219 | 21 | 46847898 | COL18A1 | Body | shore | −0.009 | 3.90E-07 | −0.005 | 0.008 | 0.000 | 0.990 | |
cg15477600 | 22 | 21996253 | SDF2L1 | TSS1500 | island | −0.002 | 1.57E-06 | −0.001 | 0.004 | −0.000 | 0.691 | ✓ |
aLinear regression analyses adjusted for the sex of child were applied to determine the associations of DNA methylation levels with ln-transformed BPA levels in the Taiwan cohort.
bAdjusted for maternal age, maternal educational levels, maternal pre-pregnancy BMI, maternal smoking during pregnancy, gestational age, and cord blood cell estimates.
cAdjusted for maternal age, maternal educational levels, maternal pre-pregnancy BMI, maternal smoking during pregnancy, gestational age, infant sex, and cord blood cell estimates.
dPartial regression coefficient indicates absolute DNA methylation change per ln-unit increase in BPA concentration.
Chr, chromosome; TSS, transcription start site; TSS200, 200 bases from TSS; TSS1500, 1500 bases from TSS; Body; gene body; UTR, untranslated region; NA, not available.