Table 5.
Top 10 enriched KEGG pathways ranked by the lowest p-value associated with genes annotated to the CpGs with p < 0.0001 from the male- and female-only analyses.
| KEGG pathway description | N | DE | P.DE | FDR |
|---|---|---|---|---|
| Male only analysis | ||||
| Phagosome | 142 | 5 | 3.85E-05 | 0.002 |
| MAPK signaling pathway | 283 | 7 | 6.28E-05 | 0.002 |
| AMPK signaling pathway | 117 | 5 | 7.51E-05 | 0.002 |
| Focal adhesion | 191 | 6 | 8.16E-05 | 0.002 |
| Rap1 signaling pathway | 203 | 6 | 8.60E-05 | 0.002 |
| Signaling pathways regulating pluripotency of stem cells | 135 | 5 | 1.35E-04 | 0.003 |
| mTOR signaling pathway | 147 | 5 | 1.59E-04 | 0.003 |
| Cellular senescence | 153 | 5 | 1.72E-04 | 0.003 |
| Phospholipase D signaling pathway | 142 | 5 | 2.07E-04 | 0.003 |
| Natural killer cell-mediated cytotoxicity | 105 | 4 | 2.29E-04 | 0.003 |
| Female only analysis | ||||
| cAMP signaling pathway | 192 | 8 | 9.13E-07 | 1.5E-04 |
| Estrogen signaling pathway | 136 | 7 | 9.36E-07 | 1.5E-04 |
| Relaxin signaling pathway | 125 | 6 | 1.19E-05 | 0.001 |
| Th17 cell differentiation | 102 | 5 | 3.43E-05 | 0.001 |
| Wnt signaling pathway | 140 | 6 | 3.54E-05 | 0.001 |
| Cell cycle | 121 | 5 | 7.76E-05 | 0.002 |
| Platelet activation | 122 | 5 | 9.80E-05 | 0.002 |
| B cell receptor signaling pathway | 68 | 4 | 1.20E-04 | 0.003 |
| Parathyroid hormone synthesis, secretion, and action | 105 | 5 | 1.21E-04 | 0.003 |
| Cytokine-cytokine receptor interaction | 265 | 5 | 2.64E-04 | 0.004 |
N, total genes in the KEGG pathway; DE, the number of genes within the CpGs with p < 0.0001; FDR, FDR-adjusted p-value for enrichment.