Table 1.
Pathway Analysis of Significant Genes Identified with CRISPR/Cas9 Screen
| Gene Set Name | # Genes in Gene Set (K) | # Genes in Overlap (k) | k/K | p Value | FDR Q-Value |
|---|---|---|---|---|---|
| KEGG | |||||
| Pathways in cancer | 328 | 54 | 16.5% | 4.47 × 10−17 | 8.32 × 10−15 |
| Focal adhesion | 201 | 35 | 17.4% | 2.67 × 10−12 | 2.48 × 10−10 |
| Mapk signaling pathway | 267 | 40 | 15.0% | 1.08 × 10−11 | 6.71 × 10−10 |
| Erbb signaling pathway | 87 | 20 | 23.0% | 8.10 × 10−10 | 3.63 × 10−8 |
| Calcium signaling pathway | 178 | 29 | 16.3% | 9.77 × 10−10 | 3.63 × 10−8 |
| Endometrial cancer | 52 | 15 | 28.9% | 3.62 × 10−9 | 1.12 × 10−7 |
| Chemokine signaling pathway | 190 | 29 | 15.3% | 4.59 × 10−9 | 1.22 × 10−7 |
| Adherens junction | 75 | 17 | 22.7% | 1.86 × 10−8 | 3.85 × 10−7 |
| B cell receptor signaling pathway | 75 | 17 | 22.7% | 1.86 × 10−8 | 3.85 × 10−7 |
| Insulin signaling pathway | 137 | 23 | 16.8% | 2.87 × 10−8 | 5.33 × 10−7 |
| GO Biological Processes | |||||
| Phosphate-containing compound metabolic process | 1,977 | 245 | 12.4% | 2.47 × 10−50 | 1.10 × 10−46 |
| Response to external stimulus | 1,821 | 229 | 12.6% | 4.74 × 10−48 | 1.05 × 10−44 |
| Regulation of transport | 1,804 | 227 | 12.6% | 1.15 × 10−47 | 1.70 × 10−44 |
| Positive regulation of gene expression | 1,733 | 217 | 12.5% | 3.45 × 10−45 | 3.83 × 10−42 |
| Protein localization | 1,805 | 222 | 12.3% | 5.69 × 10−45 | 5.05 × 10−42 |
| Positive regulation of response to stimulus | 1,929 | 231 | 12.0% | 7.09 × 10−45 | 5.24 × 10−42 |
| Positive regulation of biosynthetic process | 1,805 | 220 | 12.2% | 6.30 × 10−44 | 3.99 × 10−41 |
| Response to endogenous stimulus | 1,450 | 192 | 13.2% | 1.98 × 10−43 | 1.10 × 10−40 |
| Regulation of cell proliferation | 1,496 | 193 | 12.9% | 5.22 × 10−42 | 2.57 × 10−39 |
| Regulation of intracellular signal transduction | 1,656 | 204 | 12.3% | 2.20 × 10−41 | 9.74 × 10−39 |
| GO Molecular Function | |||||
| Ribonucleotide binding | 1,860 | 225 | 12.1% | 2.10 × 10−44 | 1.89 × 10−41 |
| Adenyl nucleotide binding | 1,514 | 197 | 13.0% | 1.96 × 10−43 | 8.81 × 10−41 |
| Receptor binding | 1,476 | 185 | 12.5% | 1.54 × 10−38 | 4.64 × 10−36 |
| Enzyme binding | 1,737 | 193 | 11.1% | 5.23 × 10−33 | 1.18 × 10−30 |
| Receptor activity | 1,649 | 185 | 11.2% | 3.52 × 10−32 | 6.35 × 10−30 |
| Kinase activity | 842 | 118 | 14.0% | 3.97 × 10−29 | 5.97 × 10−27 |
| Signal transducer activity | 1,731 | 183 | 10.6% | 1.21 × 10−28 | 1.56 × 10−26 |
| Molecular function regulator | 1,353 | 156 | 11.5% | 1.72 × 10−28 | 1.94 × 10−26 |
| Transferase activity transferring phosphorus-containing groups | 992 | 125 | 12.6% | 1.93 × 10−26 | 1.93 × 10−24 |
| Protein kinase activity | 640 | 91 | 14.2% | 3.63 × 10−23 | 3.27 × 10−21 |
Related to Figure 1.