Table 2.
Pathway Analysis of Significant Genes Identified with RNA-Sequencing
| Gene Set Name | # Genes in Gene Set (K) | # Genes in Overlap (k) | k/K | p Value | FDR Q-Value |
|---|---|---|---|---|---|
| KEGG | |||||
| Pathways in cancer | 328 | 26 | 7.9% | 7.97 × 10−11 | 1.48 × 10−8 |
| Focal adhesion | 201 | 17 | 8.5% | 5.76 × 10−8 | 5.36 × 10−6 |
| Dilated cardiomyopathy | 92 | 11 | 12.0% | 4.06 × 10−7 | 2.52 × 10−5 |
| ECM-receptor interaction | 84 | 10 | 11.9% | 1.42 × 10−6 | 5.48 × 10−5 |
| Hypertrophic cardiomyopathy (HCM) | 85 | 10 | 11.8% | 1.59 × 10−6 | 5.48 × 10−5 |
| TGF-beta signaling pathway | 86 | 10 | 11.6% | 1.77 × 10−6 | 5.48 × 10−5 |
| Complement and coagulation cascades | 69 | 9 | 13.0% | 2.20 × 10−6 | 5.85 × 10−5 |
| Cell adhesion molecules (CAMs) | 134 | 12 | 9.0% | 2.79 × 10−6 | 6.48 × 10−5 |
| Regulation of actin cytoskeleton | 216 | 15 | 6.9% | 4.09 × 10−6 | 8.46 × 10−5 |
| Arachidonic acid metabolism | 58 | 8 | 13.8% | 5.28 × 10−6 | 9.82 × 10−5 |
| GO Biological Processes | |||||
| Tissue development | 1,518 | 138 | 9.1% | 1.12 × 10−60 | 4.98 × 10−57 |
| Regulation of multicellular organismal development | 1,672 | 138 | 8.3% | 1.45 × 10−55 | 3.21 × 10−52 |
| Positive regulation of developmental process | 1,142 | 103 | 9.0% | 1.23 × 10−44 | 1.82 × 10−41 |
| Epithelium development | 945 | 94 | 10.0% | 2.79 × 10−44 | 3.09 × 10−41 |
| Regulation of cell proliferation | 1,496 | 116 | 7.8% | 9.54 × 10−44 | 8.46 × 10−41 |
| Regulation of anatomical structure morphogenesis | 1,021 | 94 | 9.2% | 1.87 × 10−41 | 1.38 × 10−38 |
| Regulation of cell differentiation | 1,492 | 111 | 7.4% | 3.89 × 10−40 | 2.46 × 10−37 |
| Positive regulation of multicellular organismal process | 1,395 | 106 | 7.6% | 4.00 × 10−39 | 1.99 × 10−36 |
| Positive regulation of response to stimulus | 1,929 | 125 | 6.5% | 4.05 × 10−39 | 1.99 × 10−36 |
| Neurogenesis | 1,402 | 106 | 7.6% | 6.26 × 10−39 | 2.78 × 10−36 |
| GO Molecular Function | |||||
| Receptor binding | 1,476 | 107 | 7.3% | 1.16 × 10−37 | 1.05 × 10−34 |
| Molecular function regulator | 1,353 | 82 | 6.1% | 9.58 × 10−24 | 4.32 × 10−21 |
| Receptor activity | 1,649 | 90 | 5.5% | 7.09 × 10−23 | 2.13 × 10−20 |
| Signal transducer activity | 1,731 | 90 | 5.2% | 1.82 × 10−21 | 4.10 × 10−19 |
| Transporter activity | 1,276 | 74 | 5.8% | 2.11 × 10−20 | 3.80 × 10−18 |
| Transmembrane transporter activity | 997 | 63 | 6.3% | 2.50 × 10−19 | 3.75 × 10−17 |
| Enzyme binding | 1,737 | 86 | 5.0% | 3.28 × 10−19 | 4.22 × 10−17 |
| Sequence specific DNA binding | 1,037 | 61 | 5.9% | 2.84 × 10−17 | 3.20 × 10−15 |
| Calcium ion binding | 697 | 49 | 7.0% | 4.22 × 10−17 | 4.22 × 10−15 |
| RNA polymerase II transcription factor activity sequence specific DNA binding | 629 | 46 | 7.3% | 8.93 × 10−17 | 8.05 × 10−15 |
Related to Figure 3.