Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 20;13:381. doi: 10.3389/fncel.2019.00381

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Penisson, Ladewig, Belvindrah and Francis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Putative model describing the signaling pathways and other genes suggested to be involved in bRG generation. Canonical pathways currently demonstrated to promote bRG production include the FGF-MAPK axis, PDGFD signaling, PTEN/AKT/mTOR, and SHH pathways. Human/hominoid specific genes depicted in this figure include TBC1D3, a RABGAP protein that promotes Erk signaling and appears to repress Trnp1 expression, and TMEM14B, a transmembrane protein that promotes IQGAP1 translocation to the nucleus to regulate cell cycle progression. ARHGAP11B and Aspm are not indicated here as their function are either unclear or they do not obviously fit in the pathways with current knowledge. AJ, adherens junction; ECM, extracellular matrix.