TABLE 2.

List of genetic tools used to promote or impair bRG generation.

Gene/Protein	Animals	Constructs	References
ARHGAP11B	–	pCMV6-AC-ARHGAP11B (Origene, SC324558)	Florio et al., 2015
		pCAGGS-ARHGAP11B	Florio et al., 2016
Aspm	Aspm KO ferrets	–	Johnson et al., 2018
	Aspm KO mice
Baf155	Baf155 fl/fl mice X Emx1:CRE mice	pCIG2-Cre-ires-eGFP	Narayanan et al., 2018
Cdh1		pCAG-DN-Cdh1	Martínez-Martínez et al., 2016
FGFR1, MEK, ERK, ETV4	–	pCAG-MekDD-IRES-EGFP, pCAG-Etv4-IRES-EGFP, pCAG-Etv5-IRES-EGFP, pCAG-FGFR1K656E-IRES-EGFP	Heng et al., 2017
FGFRs	–	pCAG-sFGFR3 (DN)	Matsumoto et al., 2017
Hif1α	Hif1(α fl/fl mice X Nestin:Cre mice)	–	Wagenführ et al., 2015
INSM1	–	pCAG-Insm1-IRES-mCherry, pCas9-Plekha7	Tavano et al., 2018
LGN	–	pCAG-Floxp-FLAG-LGN-C	Shitamukai et al., 2011
Pax6	Tis21:CreERT2 mice	pCAGGS–LoxP-GAP43-GFP-LoxP-Pax6-IRES-nRFP	Wong et al., 2015
	Pax6fl/fl mice X Emx1:CRE mice	pCIG2-Cre-ires-eGFP	Narayanan et al., 2018
PDGFD/PDGFR signaling	–	pCAG-PDGFD-IRES-GFP	Lui et al., 2014
PTEN	–	gRNA for CRISPR/Cas9 mediated editing of human PTEN: 5′-aaacaaaaggagatatcaag-3′; FUW-DN-AKT and FUW-CA-AKT lentivirus constructs	Li et al., 2017
		gRNA for CRISPR/Cas9 mediated editing of mouse Pten: 5′-agatcgttagcagaaacaaaagg-3′
SmoM2	Gt(ROSA)26Sortm1(Smo/EYFP)Amc X GFAP:Cre	–	Wang et al., 2016a
TBC1D3	Nestin:TBC1D3	pCS2-cMyC-TBC1D3, pCAGGS-TBC1D3-IRES-EGFP	Ju et al., 2016
		pSuper-siTBC1D3
TMEM14B	–	pCMV-3 Falg-TMEM14B-EGFP; pCMV-3 Falg-IQGAP1-EGFP	Liu et al., 2017
Trnp1	–	pSuper.GFPNEO_shRNA	Stahl et al., 2013
		rv:DN-Trnp1	Martínez-Martínez et al., 2016