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. 2019 Aug 20;9:782. doi: 10.3389/fonc.2019.00782

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Copyright © 2019 Monfared, Jahangard, Nikkhah, Mirnajafi-Zadeh and Mowla.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cell viability assay in the U87-MG cells exposed to the engineered exosomes. (A) The MTT assay (MTT absorbance at 570 nm) demonstrated a significant increase in the cell viability of U87-MG cells treated with miR-21 enriched exosomes (P < 0.0001 at 24 h, and P < 0.05 at 48 h). (B) MTT absorbance in U87-MG cells revealed a significant decreased in cell viability, in the cells exposed to the miR-21-sponge containing exosomes (P < 0.001 at 24 h, and P < 0.05 at 48 h). The cells exposed to the mock-vectors containing exosomes were used as controls. ^*P < 0.05; ^***P < 0.001; ^****P < 0.0001, which is represented by some statistical software like Graph Pad.