Table 2.
Presenting signs and symptoms of patients with leptomeningeal metastasis attributed to cerebral, cranial nerve, and spinal affection.
| Clinical manifestation | Solid malignancies (n = 76) | Hematological malignancies (n = 37) | p-value |
|---|---|---|---|
| Cerebral symptoms | 78% | 49% | 0.003 |
| Headache | 34% | 22% | 0.20 |
| Consciousness disturbance | 24% | 19% | 0.64 |
| Brainstem/Cerebellar signs | 22% | 8% | 0.07 |
| Seizures | 18% | 8% | 0.17 |
| Nausea/Vomiting | 17% | 5% | 0.14 |
| Cranial nerve symptoms | 26% | 46% | 0.05 |
| Nervus opticus (II) | 35% | 18% | 0.29 |
| Nervus oclumotorius (III) | 20% | 18% | 1.0 |
| Nervus trigeminus (V) | 5% | 24% | 0.16 |
| Nervus abducencs (VI) | 20% | 35% | 0.46 |
| Nervus facialis (VII) | 20% | 53% | 0.05 |
| Nervus vestibulocochlearis (VIII) | 35% | 12% | 0.14 |
| Nervus vagus (X) | 10% | 0% | 1.0 |
| Other cranial nerves | 10% | 6% | 1.0 |
| Spinal symptoms | 26% | 27% | 1.0 |