Table 1.

Ideal Brucella vaccine (107).

1. Constituted by living bacteria able to generate a potent Th1-type response.

2. Not induce the production of antibodies that may interfere with diagnosis tests to detect infected animals.

3. An attenuated strain that does not cause disease nor persistent infection in animal.

4. Not be pathogenic for humans, preventing accidental contamination during the administration of the vaccine.

5. Induce long-term protection with only one dose, without causing abortions even when administered to pregnant females.

6. Not induce antibody response when applying boosters.

7. Stable and not revert to its virulent state in vivo or in vitro.

8. Affordable for its massive application and easy to produce and administer.