Figure 3.

Kv channels kinetic map at 25°C. (A) Illustration of activation stimulus with 20 mV steps and evoked current response are shown (top left panel). The amplitude is indicated in nA with scale bar. The non-transfected CHO-FT cell line is shown as control for the background current (top right panel). Representative traces of the typical response to activation stimulus for each Kv channel, recorded at 25°C, is shown. Current traces are sorted by Kv subfamily. ★ indicates a channel with inherent kinetic heterogeneity (see also Figure 6); for these channels, only one from a range of recorded responses is shown. (B) Box plots of AI values for each Kv channel at 25°C; ion channels are ordered by their median AI values and categorized as active or silent based on the 0.3 cut-off value for the 3rd quartile of the box plot (N = 3,409 cells). Active channels are further divided into highly active or low active based on 0.3 cut-off value for the median value of the box plot.