Figure 8.

Kv1.1 temperature-dependent H-H modeling. (A) Kv1.1 CHO cells recorded from three different temperatures are used for H-H model fitting. An example of the fit to normalized conductance for cells recorded at three different temperatures, 15°C (blue), 25°C (black), and 35°C (red) is shown (see Methods “H-H model fitting”). (B) Voltage-dependent m_∞, h_∞, m_τ, h_τ parameters are plotted (in dots) for all fitted cells. Median values, fitted with a smooth function, are represented with solid lines. (C) Voltage dependence of the m_∞ parameter is approximated with a single Boltzmann function for all three temperatures. m_τ is fitted with voltage and temperature-dependent Q₁₀. The steady state value of h_∞ is computed using the temperature-dependent linear function h_∞Q₁₀. h_τ is fitted to a Boltzmann curve with a constant Q₁₀ value of 2.7. (D) Equations used to fit the temperature-dependent Kv1.1 model.