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. 2019 Aug 26;9:12339. doi: 10.1038/s41598-019-48743-8

Table 4.

Concentration of inflammatory cytokines in serum of participants with sleep disturbance administered RBS or placebo for 2 weeks.

Parameter Placebo
(n = 21)
RBS
(n = 21)
P valuea
(Unadjusted)
P valueb
(Adjusted)
IL-1β (pg/mL) At Baseline 0.48 ± 1.16 0.45 ± 1.31 0.932
At 2 weeks 0.49 ± 0.91 0.38 ± 0.52 0.630
Difference 0.03 ± 1.03 −0.06 ± 1.16 0.783 0.672
TNF-α (pg/mL) At Baseline 1.48 ± 1.78 1.07 ± 0.71 0.327
At 2 weeks 1.56 ± 1.76 1.01 ± 0.32 0.166
Difference 0.08 ± 2.26 −0.06 ± 0.75 0.785 0.617

Data are expressed as the mean ± standard deviation.

aP values refer to independent t-tests, compared with the placebo group.

bP values refer to the analysis of covariance, adjusted for caffeine intake as a covariate.