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Schematic diagram of the mechanisms about the role of HDAC3/NF-kappaB pathway in pathogenesis and exercise therapy of OA. Moderate-intensity of exercise can inhibit nuclear translocation of HDAC3/NF-kappaB complex, leading to decreased expression of inflammatory proteins. Meanwhile, the HDAC3 inhibitor RGFP966 could also alleviate inflammation response in OA through HDAC3/NF-kappaB pathway in vivo and in vitro.
