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. 2019 Aug 20;10:1060. doi: 10.3389/fphys.2019.01060

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Copyright © 2019 Zhang, Ji, Yang, Wei, Zhang, Gang, Lu and Bai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Osteoarthritis rats were treated with RGFP966. Immunohistochemistry (IHC) was performed to measure relative inflammatory proteins in OA. (A,B) Expression of collagen II in CG and OAG + RGFP966 group was higher than OAG by IHC. (A,C) Expression of HDAC3 in CG and OAG + RGFP966 group was lower than OAG by IHC. (A,D) Expression of MMP-13 in CG and OAG + RGFP966 group was lower than OAG by IHC. (A,E) The percentage of NF-kappaB positive cell in CG and OAG + RGFP966 group were lower than OAG by IHC; ^∗∗p < 0.01; ^∗p < 0.05 vs. CG, ^##p < 0.01; ^#p < 0.05 vs. OAG + RGFP966 group; n = 5 rats for each group in IHC, means with SEM.