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. 2019 Aug 20;13:372. doi: 10.3389/fncel.2019.00372

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Copyright © 2019 Pérez, Morales, Santander, García, Gómez, Peñaloza-Sancho, Fuentealba, Dagnino-Subiabre, Moya and Fuenzalida.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Late Adolescence ketamine treatment reduces the number of PV+ and GAD67+ cells and its immunoreactivity in layer II/III of the mPFC. (A) Confocal images of slices from the mPFC stained for parvalbumin (green) and GAD67 (red) from Veh (A1) and Ket (A2) animals. (B) Examples of colocalization of PV, GAD67, and DAPI (blue) in samples from Veh (B1) and Ket (B2) animals. (C) Summary data show that late adolescence Ket treatment significantly reduces the number of both PV cells and GAD67 cells among all DAPI cells in layer II/III of the mPFC compared to the Veh group (t-test, ^∗∗p < 0.01). (D) Prefrontal brain slices from Ket animals showed a reduction of fluorescence intensity in both PV and GAD67 compared to the Veh group (t-test, ^∗p < 0.05). (E) Confocal images of slices from CA1 area of vHPC stained for PV (green) and GAD67 (red) from Veh (A1) and Ket (A2) animals. (F) Examples of colocalization of PV, GAD67, and DAPI (blue) in samples from Veh (F1) and Ket (F2) animals. (G) Summary data show that Ket administration did not affect the number of both PV cells and GAD67 cells in the CA1 area of vHPC compared to Veh group (t-test, ^∗p > 0.05). (H) No changes were detected in both PV and GAD67 fluorescence intensity in Ket-treated animals compared to the Veh group (t-test, ^∗p > 0.05). Data are the mean ± SEM. The number of animals is indicated in parentheses or within bars. ^∗p > 0.05, ^∗∗p > 0.001, and ^∗∗∗p > 0.0001.