Table 1.
SNPs in FTO locus.
| FTO SNPs | Phenotype observed | Region or country of population studied | Number of studies | Total enrollment across all studies, (n = subjects + healthy controls) | References |
|---|---|---|---|---|---|
| rs9939609 (Intron 1) | Correlations with increased BMI, obesity, and in a few divergent studies increased risk for metabolic diseases (ex: T2D or insulin sensitivity), though a few studies reported no direct correlation for T2D. Some studies also showed that diet or exercise can attenuate some of the effects or heightened risk of SNP presence | Denmark, Finland, Europe, Germany, Brazil, Spain, United States, Japan, Netherlands, South Asia, Asia, Africa, China, Portugal | 18 | 518,014 | (28–44) |
| rs9930506 (Intron 1) | Correlation with BMI, hip circumference and total body weight in Sardinian patients and validated using 3,467 GenNet samples | Sardinia | 1 | 6,148 | (45) |
| rs8050136 (Intron 1) | Correlation with BMI and obesity, but not with insulin sensitivity, and second study found FTO SNP does not affect weight loss post-pregnancy | Germany and United States | 2 | 1,700 | (46, 47) |
| rs17818902 (Intron 1) | No direct correlation between BMI or obesity to specific SNP | Czech Republic | 1 | 107 | (48) |
| rs17817449 (Intron 1) | SNP correlates with 22% increased risk of obesity in adults and children | Europe | 1 | 8,000 | (5) |
| rs1558902 (Intron 1) | SNP does not affect weight loss following obesity | United States | 1 | 742 | (49) |
| rs1421085 (Intron 1) | Increased risk for obesity and/or T2D with SNP presence, but physical activity can attenuate effects | Europe and Global | 2 | 22,585 | (50, 51) |
| rs1121980 (Intron 1) | Increased risk for obesity and higher BMI with SNP presence, but physical activity can attenuate effects | Europe | 2 | 131,795 | (52, 53) |
The association between SNPs of fat mass- and obesity-associated (FTO) gene resulting in an impact on the development of obesity-associated phenotypes in multi-ethnic populations in different countries.