Table 1.
Child–Pugh classification for participants with hepatic impairment13
| Measurement | 1 point | 2 points | 3 points |
|---|---|---|---|
| Albumin (g L−1) | >35 | 28–35 | <28 |
| Ascites | Absent | Slight quantity | Moderate quantity |
| Bilirubin (mg dL−1) | <2 mg dL−1 | 2–3 mg dL−1 | >3 mg dL−1 |
| Hepatic encephalopathya | None | I–II | III–IV |
| Prothrombin time (Quick's test value; %) | >60 | 40–60 | <40 |
The degree of hepatic impairment was classified as CP‐A (5–6 points) or CP‐B (7–9 points). Participants with CP‐C (10–15 points) were not eligible for study enrolment. CP‐A, Child–Pugh classification grade A; CP‐B, Child–Pugh classification grade B.
a
Encephalopathy Grading System:
Grade I: restless, sleep disturbed, irritable/agitated, tremor, impaired handwriting
Grade II: lethargic, time‐disoriented, inappropriate, asterixis, ataxia
Grade III: somnolent, stuporous, place‐disoriented, hyperactive reflexes, rigidity
Grade IV: unrousable coma, no personality/behaviour, decerebrate.