Table 2.
Demographic and baseline characteristics
| Matched control mild hepatic impairment n = 9 (100%) | Mild hepatic impairment n = 9 (100%) | Matched control moderate hepatic impairment n = 9 (100%) | Moderate hepatic impairment n = 9 (100%) | Total n = 36 (100%) | |
|---|---|---|---|---|---|
| Gender | |||||
| Male, n (%) | 6 (66.7) | 6 (66.7) | 6 (66.7) | 6 (66.7) | 24 (66.7) |
| Female, n (%) | 3 (33.3) | 3 (33.3) | 3 (33.3) | 3 (33.3) | 12 (33.3) |
| Race | |||||
| White, n (%) | 9 (100.0) | 9 (100.0) | 9 (100.0) | 9 (100.0) | 36 (100.0) |
| Age (y), mean ± SD | 58.7 ± 6.7 | 60.2 ± 6.0 | 63.6 ± 9.8 | 66.9 ± 9.7 | 62.3 ± 8.5 |
| Weighta (kg), mean ± SD | 82.20 ± 18.33 | 82.86 ± 18.03 | 81.91 ± 15.37 | 85.17 ± 17.74 | 83.03 ± 16.70 |
| Heighta (cm), mean ± SD | 174.67 ± 11.01 | 174.00 ± 7.86 | 174.89 ± 9.97 | 172.78 ± 6.51 | 174.08 ± 8.66 |
| BMIa (kg m-2), mean ± SD | 26.69 ± 3.92 | 27.12 ± 4.53 | 26.58 ± 3.11 | 28.32 ± 4.67 | 27.18 ± 3.99 |
| Smoking history | |||||
| Never | 5 (55.6%) | 1 (11.1%) | 6 (66.7%) | 3 (33.3%) | 15 (41.7%) |
| Former | 1 (11.1%) | 3 (33.3%) | 1 (11.1%) | 3 (33.3%) | 8 (22.2%) |
| Current | 3 (33.3%) | 5 (55.6%) | 2 (22.2%) | 3 (33.3%) | 13 (36.1%) |
| Other tobacco | |||||
| Never | 8 (88.9%) | 8 (88.9%) | 9 (100.0%) | 9 (100.0%) | 34 (94.4%) |
| Former | 0 | 1 (11.1%) | 0 | 0 | 1 (2.8%) |
| Current | 1 (11.1%) | 0 | 0 | 0 | 1 (2.8%) |
| Alcohol use | |||||
| Abstinent | 6 (66.7%) | 7 (77.8%) | 5 (55.6%) | 8 (88.9%) | 26 (72.2%) |
| Light | 3 (33.3%) | 2 (22.2%) | 4 (44.4%) | 1 (11.1%) | 10 (27.8%) |
| Laboratory parameters, mean ± SDb | |||||
| Albumin (g dL−1) | 4.31 ± 0.23 | 4.17 ± 0.30 | 4.33 ± 0.23 | 3.88 ± 0.52 | ‐ |
| Bilirubin (mg dL−1) | 0.533 ± 0.390 | 0.600 ± 0.492 | 0.411 ± 0.127 | 0.867 ± 0.730 | ‐ |
| Child–Pugh score, n | |||||
| 5 | ‐ | 5 | ‐ | ‐ | ‐ |
| 6 | ‐ | 4 | ‐ | ‐ | ‐ |
| 7 | ‐ | ‐ | ‐ | 5 | ‐ |
| 8 | ‐ | ‐ | ‐ | 1 | ‐ |
| 9 | ‐ | ‐ | ‐ | 3 | ‐ |
BMI, body mass index; SD, standard deviation.
a
At screening.
b
Values calculated for all control participants (pooled matched control participants with mild and moderate hepatic impairment, n=18)