Table 4.

Limited sampling schemes based on 1 or multiple time points

Time points blood sampling	R2 Pearson	Percentage of AUCpred within 10% range of AUCfull	Percentage of AUCpred within 15% range of AUCfull	Percentage of AUCpred within 20% range of AUCfull	MPE (mg*h/L)	MPPE (%)	RMSE (mg*h/L)	MAPE (%)
No sampling (population prediction)	0.01	22.86	31.43	40.00	−52.60	4.23	543.45	23.83
T = 1.5	0.67	54.29	68.57	82.86	−29.17	0.41	291.71	11.65
T = 4/7	0.97	91.43	97.14	100	11.01	0.59	101.79	5.06
T = 1.5/3.5	0.93	77.14	94.29	97.14	−26.76	−0.66	138.88	5.62
T = 5/7/9	0.96	82.86	94.29	100	−6.23	−0.49	112.20	5.86
T = 3.5/4/7	0.96	82.86	97.14	100	−0.81	−0.06	103.74	5.07
T = 1.5/3.5/4	0.97	91.43	97.14	100	−2.86	0.53	100.09	3.92
T = 4/5/7	0.97	91.43	100	100	2.54	0.13	89.83	4.82
T = 1.5/4/5	0.98	97.14	100	100	−9.00	0.01	77.84	3.28
T = 1.5/4/7	0.99	100	100	100	0.61	−0.05	61.62	2.84
T = 1.5/3.5/4/5	0.99	100	100	100	−7.91	0.01	61.93	2.41
T = 1.5/4/5/7/9	0.99	100	100	100	−0.67	−0.07	45.98	1.91
T = 1.5/3.5/4/7/9	1.00	100	100	100	1.43	0.06	18.72	0.82

AUC_pred: predicted area under the curve; AUC_full: full or true area under the curve; MPE: mean prediction error; MPPE: mean percentage prediction error; RMSE: root mean squared prediction error; MAPE: mean absolute percentage predictive error.