Figure 5.
With baseline parametrization and a range of cell–cell force strengths the model can be parametrized such that the plug stays intact over a long period. Grey black lines show model results with parameters as in table 1, and grey lines show predictions with acc at 2× baseline values. (a) The percentage of cells within two cell radii of the vessel wall is low and stable over time, except for an initial transient, (b) while porosity increases over time, changes are small and within the expected physiological range, (c) average z-velocity of cells is small and in the direction of flow (horizontal dashed line shows expected migration rate along the vessel wall), and (d) increases in predicted blood flow within the artery for a fixed pressure drop are small. (e) There are some changes in cell configuration from initial seeding; however, the plug remains relatively intact. (Online version in colour.)