Table 1.
Model parameters, ranges and descriptions.
parameter | description | range | value | references |
---|---|---|---|---|
geometric parameters | ||||
spiral artery radius (µm) | — | 200 | [5] | |
trophoblast diameter (µm) | 30–40 | 40 | [15,23] | |
L | length of decidual spiral artery modelled (mm) | — | 1 | see text |
Zp2 − Zp1 | plug length (mm) | >0.115 | 0.5 | [23,24] |
Zp1 | plug distance from IVS (mm) | — | 0.1 | — |
blood flow parameters | ||||
μ | blood viscosity (Pa s) | 0.003 | 0.003 | [10,43] |
ΔP | pressure drop along segment of spiral artery (mmHg) | — | 55 | from [10] |
drag force | ||||
kd | drag constant (N s m−1) | — | 1.13 × 10−6 | see text |
random force, Frandom | ||||
D | diffusion constant (N) | — | 2.83 × 10−13 | fit to data |
flow force, Fflow | ||||
a | constant of proportionality (N s m−1) | — | 1.13 × 10−8 | fit to data |
cell–wall interaction, Fcw | ||||
acw | scaling factor of the basic Fcw force function (N) | — | 1.88 × 10−14 | see text |
bcw | maximum attractive Fcw force (N) | — | 1.04 × 10−14 | fit to data |
r0 | location of lower asymptote of force (fraction of cell diameter) | — | 0.3 | see text |
r1 | location of upper asymptote of force (fraction of cell diameter) | — | 1.7 | see text |
cell–cell interaction, Fcc | ||||
acc | scaling factor of the basic Fcc force function (N) | — | 1.88 × 10−14 | see text |
bcc | maximum attractive Fcc force (N) | — | 7.54 × 10−16 | unknown |
r0 | location of lower asymptote of force (fraction of cell diameter) | — | 0.3 | see text |
r1 | location of upper asymptote of force (fraction of cell diameter) | — | 1.7 | see text |
chemotaxis, Fchem | ||||
fax | magnitude of chemoattractant force in axial direction (N) | — | 1.88 × 10−16 | unknown |
cax | coefficient controlling the penetration depth of axial chemoattractant force into the SA lumen (no units) | — | 1 | unknown |
frad | magnitude of chemoattractant force in radial direction (N m−1) | — | 1.88 × 10−11 | unknown |
crad | coefficient controlling the penetration depth of radial chemoattractant force into the SA lumen (no units) | — | 1 | unknown |