Table 2.
Dosimetric Results for Normal Brain Tissue of NC-VMAT, C-VMAT, IMRT, and CK Plans (Mean ± SD).a
| OARs | NC-VMAT | C-VMAT | P | IMRT | P | CK | P | |
|---|---|---|---|---|---|---|---|---|
| Normal brain tissue volume, cm3 | V 24Gy | 15.85 ± 7.05 | 17.40 ± 8.64 | .010 | 20.45 ± 8.31 | .001 | 17.98 ± 9.10 | .100 |
| V 21Gy | 25.97 ± 12.44 | 29.81 ± 15.73 | .001 | 34.32 ± 15.55 | .001 | 28.66 ± 14.70 | .156 | |
| V 18Gy | 41.19 ± 21.45 | 49.39 ± 26.96 | .001 | 55.57 ± 26.92 | .001 | 41.63 ± 21.86 | .820 | |
| V 15Gy | 68.19 ± 38.89 | 88.69 ± 53.71 | .001 | 94.49 ± 48.74 | .001 | 61.60 ± 33.02 | .100 | |
| V 12Gy | 124.69 ± 79.48 | 165.98 ± 109.97 | .001 | 168.56 ± 96.88 | .001 | 94.97 ± 52.41 | .015 | |
| V 9Gy | 236.12 ± 157.32 | 285.76 ± 177.29 | .001 | 280.76 ± 172.16 | .008 | 171.50 ± 104.34 | .003 | |
| V 6Gy | 435.47 ± 276.56 | 467.69 ± 250.10 | .088 | 424.23 ± 230.52 | .955 | 324.49±199.67 | .004 | |
| V 3Gy | 793.03 ± 371.40 | 742.99 ± 302.19 | .156 | 635.20 ± 274.93 | .005 | 597.33 ± 293.26 | .001 | |
a Statistical significance was tested for each technology in comparison with NC-VAMT.
Abbreviations: CK, CyberKnife; C-VMAT, coplanar VMAT; IMRT, intensity-modulated radiation therapy; NC-VMAT, noncoplanar volumetric modulated arc therapy; OARs, organs at risk; SD, standard deviation.