Table 2.
Genotype and allele distribution of TAB2 gene polymorphisms in patients with epithelial ovarian cancer and healthy controls.
| Genotype or allele | Case N = 221 (%) |
Control N = 252 (%) |
OR (95% CI) | P value | |
|---|---|---|---|---|---|
| rs237028 Genetic model |
Genotype | ||||
| Codominant | A/A | 144 (66.4) | 137 (54.4) | 1.00 | 0.03∗ |
| A/G | 61 (28.1) | 97 (38.5) | 1.67 (1.12-2.49) | ||
| G/G | 12 (5.5) | 18 (7.1) | 1.58 (0.73-3.39) | ||
| Dominant | A/A | 144 (66.4) | 137 (54.4) | 1.00 | 0.008∗ |
| A/G-G/G | 73 (33.6) | 115 (45.6) | 1.66 (1.14-2.41) | ||
| Recessive | A/A-A/G | 205 (94.5) | 234 (92.9) | 1.00 | 0.47 |
| G/G | 12 (5.5) | 18 (7.1) | 1.31 (0.62-2.79) | ||
| Overdominant | A/A-G/G | 156 (71.9) | 155 (61.5) | 1.00 | 0.017∗ |
| A/G | 61 (28.1) | 97 (38.5) | 1.60 (1.08-2.36) | ||
| Allele | A | 349 (80) | 371 (74) | 0.016∗ | |
| G | 85 (20) | 133 (26) | 1.45 (1.07-1.96) | ||
| rs521845 Genetic model | |||||
| Codominant | T/T | 85 (40.5) | 105 (41.7) | 1.00 | 0.97 |
| T/G | 100 (47.6) | 118 (46.8) | 0.96 (0.65-1.41) | ||
| G/G | 25 (11.9) | 29 (11.5) | 0.94 (0.51-1.72) | ||
| Dominant | T/T | 85 (40.5) | 105 (41.7) | 1.00 | 0.80 |
| T/G-G/G | 125 (59.5) | 147 (58.3) | 0.95 (0.66-1.38) | ||
| Recessive | T/T-T/G | 185 (88.1) | 223 (88.5) | 1.00 | 0.89 |
| G/G | 25 (11.9) | 29 (11.5) | 0.96 (0.54-1.70) | ||
| Overdominant | T/T-G/G | 110 (52.4) | 134 (53.2) | 1.00 | 0.86 |
| T/G | 100 (47.6) | 118 (46.8) | 0.97 (0.67-1.40) | ||
| Allele | T | 270 (64) | 328 (65) | 0.96 (0.73-1.27) | 0.8 |
| G | 150 (36) | 176 (35) | |||
| rs652921 Genetic model | |||||
| Codominant | T/T | 66 (32.5) | 85 (33.7) | 1.00 | 0.53 |
| T/C | 87 (42.9) | 116 (46) | 1.04 (0.68-1.58) | ||
| C/C | 50 (24.6) | 51 (20.2) | 0.79 (0.48-1.31) | ||
| Dominant | T/T | 66 (32.5) | 85 (33.7) | 1.00 | 0.78 |
| T/C-C/C | 137 (67.5) | 167 (66.3) | 0.95 (0.64-1.40) | ||
| Recessive | T/T-T/C | 153 (75.4) | 201 (79.8) | 1.00 | 0.26 |
| C/C | 50 (24.6) | 51 (20.2) | 0.78 (0.50-1.21) | ||
| Overdominant | T/T-C/C | 116 (57.1) | 136 (54) | 1.00 | 0.5 |
| T/T | 87 (42.9) | 116 (46) | 1.14 (0.78-1.65) | ||
| Allele | T | 219 (54) | 286 (57) | 0.90 (0.70-1.16) | 0.42 |
| C | 187 (46) | 218 (43) | |||
CI = confidence interval, OR = odds ratio. ∗P < 0.05.