Table 3.
Association between the genotype distribution of rs237028 and characteristics of the EOC patients.
| Clinical features | Genotype | Genetic model | Allele | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Codominant | Dominant | Recessive | Overdominant | ||||||||||||
| (A/A vs. A/G vs G/G) | (A/A vs. A/G-G/G) | (A/A-A/G vs. G/G) | (A/A-G/G vs. A/G) | ||||||||||||
| A/A | A/G | G/G | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | A | G | OR (95% CI) | P value | |
| Age | |||||||||||||||
| <50 | 41 | 20 | 6 | A/G: 0.658 (0.306-1.412) | 0.281 | 0.565 (0.276-1.160) | 0.118 | 0.290 (0.057-1.493) | 0.115 | 0.726 (0.341-1.545) | O.406 | 102 | 32 | 0.544 (0.296-1.001) | 0.049∗ |
| ≥50 | 53 | 17 | 2 | G/G: 0.258 (0.049-1.345) | 0.090 | 123 | 21 | ||||||||
| FIGO stage | |||||||||||||||
| I-II | 31 | 8 | 2 | A/G: 1.784 (0.730-4.357) | 0.201 | 1.722 (0.756-3.926) | 0.193 | 1.272 (0.246-6.579) | 0.564 | 1.734 (0.715-4.204) | 0.220 | 70 | 12 | 1.543 (0.764-3.115) | 0.224 |
| III-IV | 63 | 29 | 6 | G/G: 1.476 (0.282-7.741) | 0.489 | 155 | 41 | ||||||||
| Grade | |||||||||||||||
| G1 | 6 | 5 | 1 | A/G: 2.194 (0.623-7.729) | 0.182 | 2.194 (0.662-7.273) | 0.161 | 1.652 (0.182-14.994) | 0.510 | 2.024 (0.597-6.860) | 0.205 | 18 | 10 | 2.664 (1.143-6.211) | 0.020∗ |
| G2-G3 | 79 | 30 | 6 | G/G: 2.194 (0.226-21.324) | 0.437 | 187 | 39 | ||||||||
| Histology | |||||||||||||||
| Serous | 49 | 20 | 5 | A/G: 1.056 (0.492-2.286) | 0.888 | 1.122 (0.549-2.295) | 0.752 | 1.473 (0.338-6.423) | 0.443 | 1.024 (0.481-2.180) | 0.951 | 118 | 30 | 1.183 (0.647-2.161) | 0.585 |
| Others | 44 | 17 | 3 | G/G: 1.497 (0.338-6.628) | 0.438 | 107 | 23 | ||||||||
| Tumor position | |||||||||||||||
| Unilateral | 27 | 7 | 3 | A/G: 1.815 (0.693-4.753) | 0.221 | 1.429 (0.603-3.387) | 0.276 | 0.453 (0.087-2.362) | 0.293 | 1.905 (0.735-4.939) | 0.181 | 61 | 13 | 1.117 (0.544-2.293) | 0.762 |
| Bilateral | 51 | 24 | 3 | G/G: 0.529 (0.100-2.804) | 0.365 | 126 | 30 | ||||||||
| Lymph node status | |||||||||||||||
| Negative | 36 | 16 | 5 | A/G: 0.622 (0.228-1.696) | 0.352 | 0.681 (0.266-1.743) | 0.421 | 1.154 (0.209-6.377) | 0.619 | 0.624 (0.235-1.662) | 0.344 | 88 | 26 | 0.802 (0.378-1.703) | 0.565 |
| Positive | 14 | 10 | 2 | G/G: 0.972 (0.169-5.607) | 0.643 | 38 | 14 | ||||||||
| Peritoneum invasion | |||||||||||||||
| Negative | 32 | 13 | 3 | A/G: 0.905 (0.399-2.050) | 0.811 | 0.907 (0.423-1.944) | 0.803 | 0.947 (0.216-4.156) | 0.627 | 0.912 (0.407-2.043) | 0.495 | 77 | 19 | 0.925 (0.490-1.747) | 0.811 |
| Positive | 49 | 22 | 5 | G/G: 0.919 (0.205-4.114) | 0.613 | 120 | 32 | ||||||||
| Vascular invasion | |||||||||||||||
| Negative | 72 | 28 | 8 | A/G: 0.500 (0.170-1.472) | 0.153 | 0.643 (0.221-1.866) | 0.441 | 1.080 (1.024-1.139) | 0.320 | 0.450 (0.153-1.322) | 0.121 | 172 | 44 | 0.914 (0.371-2.250) | 0.844 |
| Positive | 9 | 7 | 0 | G/G: 1.111 (1.033-1.195) | 0.410 | 25 | 7 | ||||||||
CI = confidence interval, FIGO = International Federation of Gynecology and Obstetrics, OR = odds ratio. ∗P < 0.05.