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. 2019 Aug 14;2019:8484263. doi: 10.1155/2019/8484263

Table 2.

GRADE summary of five randomized controlled trials comparing YXQN granules plus routine treatment with nimodipine tablets plus routine treatment in chronic cerebellar circulation insufficiency.

Outcomes Anticipated absolute effects∗ (95% CI) Relative effect (95% CI) No. of participants (studies) Certainty of the evidence (GRADE)
Assumed risk: nimodipine tablets plus routine treatment Corresponding risk: YXQN granules plus routine treatment
BA blood flow velocity The mean BA blood flow velocity in the control groups was 45.37 The mean BA blood flow velocity in the intervention groups was 3.34-fold higher (2.31- to 4.37-fold higher) — 272 (3 RCTs) graphic file with name ECAM2019-8484263.tab2.i001.jpg
VA blood flow velocity The mean VA blood flow velocity in the control groups was 40.55 The mean VA blood flow velocity in the intervention groups was 3.21-fold higher (0.62- to 5.8-fold higher) — 352 (4 RCTs) graphic file with name ECAM2019-8484263.tab2.i002.jpg
ICA blood flow velocity The mean ICA blood flow velocity in the control groups was 50.7 The mean ICA blood flow velocity in the intervention groups was 7.46-fold higher (2.01- to 12.9-fold higher) — 189 (2 RCTs) graphic file with name ECAM2019-8484263.tab2.i003.jpg
Clinical efficacy of TCM symptoms 642 per 1000 883 per 1,000 (817–927) RR 4.21 (2.49 to 7.12) 386 (5 RCTs) graphic file with name ECAM2019-8484263.tab2.i004.jpg

∗The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; RR: risk ratio. GRADE Working Group grades of evidence: high certainty: we are very confident that the true effect lies close to that of the estimate of the effect; moderate certainty: we are moderately confident in the effect estimate. The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different; low certainty: our confidence in the effect estimate is limited. The true effect may be substantially different from the estimate of the effect; and very low certainty: we have very little confidence in the effect estimate. The true effect is likely to be substantially different from the estimate of the effect. aAccording to the risk-of-bias graph. bTotal number of events was less than 300.