Table 4.

Shift of mutation frequencies over time across European populations of M. graminicola for amino acid positions affecting the azole sensitivity of the CYP51 gene. All other old European and non‐European populations show the wild type.

Amino acid substitution	Frequency (%) of specific mutations
	Germany 1992	Denmark 1992	Switzerland 1999	Denmark 2005	Germany Quarnbek	Germany Dedelow
Wild type	100	33			1	1
ΔY459/G460			63	37	57	66
G460D		58	10			2
Y461H			3	52	28	15
Y461S			16	2.5	1	6
Y459P			3
Y461D			3
Y459D				7.5	10	8
Y459S					2
ΔY459						2
Y459C		8
ΔG460					1	2
I381V				95	83	37