Table 4.
Amino acid substitution | Frequency (%) of specific mutations | |||||
---|---|---|---|---|---|---|
Germany 1992 | Denmark 1992 | Switzerland 1999 | Denmark 2005 | Germany Quarnbek | Germany Dedelow | |
Wild type | 100 | 33 | 1 | 1 | ||
ΔY459/G460 | 63 | 37 | 57 | 66 | ||
G460D | 58 | 10 | 2 | |||
Y461H | 3 | 52 | 28 | 15 | ||
Y461S | 16 | 2.5 | 1 | 6 | ||
Y459P | 3 | |||||
Y461D | 3 | |||||
Y459D | 7.5 | 10 | 8 | |||
Y459S | 2 | |||||
ΔY459 | 2 | |||||
Y459C | 8 | |||||
ΔG460 | 1 | 2 | ||||
I381V | 95 | 83 | 37 |