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. 2019 Jul 11;46:317–329. doi: 10.1016/j.ebiom.2019.07.010

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 7 — Experiments on cell lines and animals indicate limited toxicity of zebularine. (A, B) Effect of increasing zebularine concentrations on the proliferation of cultured fibroblasts (46BR.1 N) and keratinocytes (HaCaT) assessed using the XTT assay after 48 and 72 h of incubation and normalized to the negative control (100%). (C) Toxicity of increasing zebularine concentrations estimated using the LDH assay after a 48-h incubation and normalized to the negative control (0%) and 1% Triton X-100 (100%). (D) Effect of zebularine injections on mouse weight. Error bars represent the SD.