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. 2019 Jul 16;46:54–65. doi: 10.1016/j.ebiom.2019.07.030

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© 2019 Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Knockdown of CDCA5 enhances the chemosensitivity of ESCC cells to cisplatin and inhibits the tumor growth in vivo. (a) Dose-response curves showing the effect of DDP at different concentrations (0, 10 μM, 20 μM, 50 μM and 100 μM) on the cells viability of KYSE30 and Eca109; (b–c) Inhibition of CDCA5 enhanced the chemosensitivity of KYSE30 (b) and Eca109 (c) cells to cisplatin (Mean ± SD, Student's t-test, ***P < .001); Lv: lentivirus transfection; (d–e) CDCA5 knockdown significantly inhibited tumor growth in vivo (both Eca109 and KYSE30 cells, (Mean ± SD, Student's t-test, **P < .01, ***P < .001)); (f) The CDCA5 knockdown efficiency in established xenograft tumors.