Table 4.

Results of longitudinal differential abundance analysis in early-life wheeze.

Differential abundance analysis: Children with doctor-confirmed wheeze (n = 26) vs. no wheeze (n = 72)
Genus	Interval start	Interval end	Differential area	p-value	Adjusted p-value
OTU42: Granulicatella	9 months	12 months	(−) 1∙118	0∙004	0∙012
OTU43: Prevotella	18 months	24 months	(−) 1∙147	0∙006	0∙018
OTU68: Neisseria	9 months	24 months	(+) 5∙993	0∙001	0∙003

Time intervals are considered of interest if the absolute difference between two groups is above 0∙2. The sign of the difference area provides information on the direction of the abundance shift. OTUs are considered differentially abundant if their adjusted p-values < 0∙05.