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. 2019 Aug 20;10:893. doi: 10.3389/fneur.2019.00893

Figure 3.

Figure 3

Immediate post-ischemic SAHA treatment reduces infarct volume and improves functional recovery in tMCAO mice. Mice subjected to 60 min of t-MCAO were injected with SAHA (50 mg/kg, i.p.) immediately or 12 h after ischemia onset. An equal volume of vehicle was injected as a control. Mice were sacrificed after 24 h, and TTC staining was performed to examine the infarct volume. (A) A representative diagram showing the brain infarction detected using TTC staining in six coronal brain sections from sham, vehicle, and two SAHA treatment groups. (B) Infarct volumes quantified by the TTC staining. **p < 0.01 vs. sham control; ##p < 0.01 vs. vehicle control, n = 6–10/group. Effects of SAHA treatment on speed (C) and distance (D) were measured before surgery and 4–14 days after the onset of I/R. **p < 0.01 compared with time point 0, #p < 0.05; ##p < 0.01 compared with I/R+vehicle group, n = 6–10/group. (E) Nissl staining of seven coronal brain sections from the sham, vehicle, and two SAHA treatment groups. (F) Infarct volumes quantified by the Nissl staining. **p < 0.01 compared with the sham group, **p < 0.01 compared with I/R+vehicle group, n = 6–10/group.