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. 2019 Aug 20;10:893. doi: 10.3389/fneur.2019.00893

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Copyright © 2019 Li, Lu, Shao, Chen, Huang, Jiao, Huang, Yue, Peng, Zhou, Chao, Zhao, Ji, Ji and Ji.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of SAHA treatment on microglia activation and macrophage infiltration in the ipsilateral hemisphere of tMCAO mice. (A) Representative dot plots depicting the gating strategy of neutrophils (Ly6G⁺), resident microglia (Ly6G⁻CD11b⁺CD45^medium), and macrophages (Ly6G⁻CD45^highCD11b⁺) from the mononuclear cells isolated from the ipsilateral hemispheres of 3 d tMCAO mouse. Dead cells were first excluded from single cells. (B) Representative dot plots showing the effects of SAHA treatment on the temporal changes of microglia and macrophages at 0.5, 1, and 3 d after the onset of brain ischemia. The temporal dynamics of microglia (C), macrophages (D) at 0.5, 1, and 3 d after I/R. *p < 0.05; **p < 0.01, compared with Sham group. ^#p < 0.05; ^##p < 0.01 compared with I/R + vehicle group. n = 4–6/group/time point.