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. 2019 Aug 20;10:893. doi: 10.3389/fneur.2019.00893

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Copyright © 2019 Li, Lu, Shao, Chen, Huang, Jiao, Huang, Yue, Peng, Zhou, Chao, Zhao, Ji, Ji and Ji.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of SAHA treatment on protein acetylation, cell morphology, and Tlr4 expression of mouse microglia. Mouse microglia were treated with 100 ng/ml LPS, 4 μM SAHA, 100 ng/ml LPS+4 μM SAHA for 12 h. Effects of treatment on protein acetylation (A), cell morphology (C), and transcription of Tlr4 (D) of mouse microglia were detected. (B) Quantification of the global lysine acetylation levels in (A). *p < 0.05; **p < 0.01 compared with normal control. ^#p < 0.05; ^##p < 0.01 compared with LPS group. Scale bar, 50 μm, n = 3/group.