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. 2019 Aug 20;10:1843. doi: 10.3389/fmicb.2019.01843

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Copyright © 2019 Hosseinzadeh, Stylianou, Lopes, Müller, Häggman, Holmberg, Grumaz, Johansson, Sohn, Dieterich and Urban.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptional dysregulation induced by tempol targets iron homeostasis and mitochondria. (A) Fold changes of mRNA expression in C. albicans after 30 or 60 min of tempol-treated (0.344 mg/ml) compared to untreated C. albicans samples. Presented genes are representative, differentially regulated genes from affected pathways as assessed according to a GO term enrichment analysis. (B) Samples described in (A) were analyzed using gene ontology enrichment of affected processes in C. albicans in response to tempol. Corresponding sets of up- and down-regulated genes were mapped to biological processes using the “GO term finder” at the Candida Genome database (CGD). X-fold enrichment is calculated as the ratio of percentages of the cluster frequency of tested gene set and the cluster frequency of genomic background.