Table 3.
Time Course of NYHA Functional Class, Vital Signs, Laboratory Data, Pulmonary Function Testing, and Cardiopulmonary Function Testing Parameters
| NYHA Functional Class, Vital Signs, and Laboratory Data | PAP, n = 31 | Non‐PAP, n = 78 | P Value | |
|---|---|---|---|---|
| NYHA class | Baseline | 2.4 ± 0.5 | 2.4 ± 0.6 | 0.488 |
| 6 months | 1.6 ± 0.5a | 2.3 ± 0.7 | ||
| Δ | −0.7 ± 0.5 | −0.2 ± 0.7 | <0.001 | |
| SBP, mm Hg | Baseline | 133.0 ± 12.9 | 123.7 ± 17.6 | 0.007 |
| 6 months | 120.7 ± 10.6b | 121.9 ± 19.4 | ||
| Δ | −12.8 ± 11.2 | −1.7 ± 16.9 | 0.001 | |
| DBP, mm Hg | Baseline | 76.7 ± 10.7 | 70.3 ± 13.3 | 0.013 |
| 6 months | 71.9 ± 7.9a | 71.0 ± 13.4 | ||
| Δ | −5.3 ± 12.2 | 0.8 ± 14.2 | 0.038 | |
| HR, bpm | Baseline | 67.7 ± 12.4 | 71.1 ± 15.4 | 0.423 |
| 6 months | 60.7 ± 10.3b | 71.2 ± 13.8 | ||
| Δ | −7.3 ± 9.2 | 0.2 ± 17.9 | 0.032 | |
| BNP, pg/mLc | Baseline | 209.1 (174.8) | 134.2 (113.8) | 0.025 |
| 6 months | 71.6 (106.0)b | 173.1 (209.9)a | ||
| Δ | −105.7 (138.0) | 27.5 (150.1) | <0.001 | |
| eGFR (mL/min/1.73 cm2) | Baseline | 60.0 ± 17.3 | 52.8 ± 22.5 | 0.162 |
| 6 months | 66.2 ± 17.6b | 52.1 ± 22.7 | ||
| Δ | 6.6 ± 6.0 | −0.8 ± 7.8 | <0.001 | |
| CRP (mg/dL)c | Baseline | 0.42 (0.48) | 0.26 (0.36) | 0.016 |
| 6 months | 0.15 (0.38)b | 0.27 (0.41) | ||
| Δ | −0.22 (0.33) | 0.04 (0.29) | <0.001 | |
| Pulmonary Function Testing | PAP, n = 17 | Non‐PAP, n = 42 | P Value | |
| FEV1 /FVC, % | Baseline | 83.9 ± 25.9 | 84.0 ± 24.5 | 0.782 |
| 6 months | 89.8 ± 29.7a | 84.9 ± 28.7 | ||
| Δ | 5.6 ± 11.1 | 1.0 ± 16.2 | 0.288 | |
| % Vital capacity | Baseline | 83.5 ± 22.3 | 85.0 ± 21.3 | 0.663 |
| 6 months | 89.9 ± 24.6b | 82.8 ± 20.2 | ||
| Δ | 6.6 ± 7.7 | −2.1 ± 13.6 | 0.020 | |
| Cardiopulmonary Exercise Testing | PAP, n = 25 | Non‐PAP, n = 46 | P Value | |
| Peak VO2, mL/kg/min | Baseline | 16.6 ± 2.6 | 15.6 ± 4.5 | 0.488 |
| 6 months | 19.6 ± 2.5a | 15.1 ± 3.2 | ||
| Δ | 3.0 ± 4.3 | −0.5 ± 3.1 | 0.035 | |
| VE/VCO2 slope | Baseline | 34.4 ± 5.8 | 34.3 ± 10.2 | 0.972 |
| 6 months | 27.1 ± 3.2a | 31.7 ± 4.2 | ||
| Δ | −7.3 ± 6.3 | −2.6 ± 8.3 | 0.190 |
Abbreviations: BNP, B‐type natriuretic peptide; CRP, C‐reactive protein; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate by the Modification of Diet in Renal Disease formula; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; HR, heart rate; IQR, interquartile range; NYHA, New York Heart Association; PAP, positive airway pressure; peak VO2, peak oxygen uptake; SBP, systolic blood pressure; VE/VCO2 slope, rate of increase in ventilation per unit increase in carbon dioxide.
a
P < 0.05.
b
P < 0.01 vs baseline.
c
Data are presented as median (IQR).