Table 2.
Left Ventricular Echocardiographic Characteristic of Studied Population
| NC‐AL, N = 34 | C‐AL, N = 45 | TTR, N = 48 | P | |
|---|---|---|---|---|
| LVEDD, mm | 45.2 ± 4.3 | 44.9 ± 6.9 | 46.1 ± 5.7 | <0.63 |
| LVESD, mm | 26.6 ± 4.8 | 29.3 ± 6.2 | 33.1 ± 6.7a | <0.0001 |
| FS % | 41.4 ± 7.2b | 34.5 ± 9.1 | 28.5 ± 8.7a | <0.0001 |
| IVS, mm | 10.3 ± 0.9b | 15.2 ± 2.6 | 17.4 ± 2.7a | <0.0001 |
| LVPW, mm | 10.3 ± 1.2b | 15 ± 2.2 | 16.3 ± 2.1a | <0.0001 |
| LV mass index, g/m2 | 97.1 ± 19.3b | 163.3 ± 36.2 | 197.4 ± 49.6a | <0.0001 |
| LA area, cm2 | 18.7 ± 3.7b | 22.7 ± 3.8 | 26.6 ± 5a | <0.0001 |
| LVEDV, mL | 80.3 ± 18.6 | 81.1 ± 27.1 | 88.5 ± 24.5 | <0.23 |
| LVESV, mL | 32.6 ± 12.5 | 34.9 ± 15.8 | 46.1 ± 20.7a | <0.001 |
| EF % | 59.6 ± 8.8 | 57.6 ± 9.2 | 49.1 ± 12.1a | <0.0001 |
| LV long strain % | −16.8 ± 7.7b | −10 ± 4.2 | −8.1 ± 3.7 | <0.0001 |
| Valve thickening, yes/no | 4 (12%)/30 (88%) | 22 (49%)/23 (51%) | 29 (60%)/19 (40%) | <0.0001 |
| Pericardial effusion, yes/no | 1 (3%)/33 (97%) | 13 (30%)/32 (70%) | 12 (25%)/36 (75%) | <0.0001 |
| Mitral regurgitation, mild–moderate/severe | 32 (94%)/2 (6%) | 35 (78%)/10 (22%) | 39 (81%)/9 (19%) | <0.14 |
| E, cm/s | 70.4 ± 18.9 | 78.5 ± 20.2 | 80.9 ± 17.1a | <0.04 |
| A, cm/s | 85.2 ± 21.4b | 58.6 ± 24.9 | 46.3 ± 22.7 | <0.0001 |
| E/A | 0.84 ± 0.2b | 1.62 ± 0.9 | 2.12 ± 1.0a | <0.0001 |
| DT, ms | 217.7 ± 68.5 | 195.1 ± 80 | 178.9 ± 66 | <0.06 |
| E′ cm/s | 7.1 ± 1.9b | 4.6 ± 1.3 | 4.6 ± 1.5 | <0.0001 |
| E/E′ | 9.9 ± 3.4b | 18.1 ± 7.1 | 19.3 ± 6.5 | <0.0001 |
| AET, ms | 289.2 ± 31.7b | 253.8 ± 37.6 | 264.3 ± 35.3 | <0.0001 |
| LV MPI | 0.36 ± 0.14b | 0.52 ± 0.21 | 0.57 ± 0.21 | <0.0001 |
Abbreviations: A, late diastolic mitral peak flow velocity; AET, aortic valve ejection time; C‐AL, cardiac AL amyloidosis; DT, decelleration time; E, early diastolic mitral peak flow velocity; E′, early diastolic peak velocity at lateral mitral annulus; FS, fractional shortening; EF, ejection fraction; IVS, interventricular septum thickness; LA, left atrium; LV, left ventricular; LVEDD, LV end‐diastolic diameter; LVEDV, LV end‐diastolic volume; LVESD, LV end‐systolic diameter; LVESV, LV end‐systolic volume; LV long strain, LV longitudinal 2‐dimensional‐speckle strain; LVPW, posterior wall thickness; MPI, myocardial performance index; NC‐AL, noncardiac AL amyloidosis; TTR, transthyretin‐related amyloidosis.
Scheffe's post hoc analysis:
TTR vs others, P < 0.05.
NC‐AL vs others, P < 0.05.