Figure 1.

Effect of oxyresveratrol pretreated orally on KA-induced neuronal death in the hippocampus Mice were pretreated orally with 50 mg/kg of oxyresveratrol (ORV) 30 min prior to KA (0.05 μg/5 μl, i.c.v.) administration. The cresyl violet staining was performed at 24 h after KA administration, and then, the cresyl violet-positive neuronal count in the hippocampal CA3 region was performed. The vertical bars in the column graph indicate the S.E.M. (***p < 0.001, control vs KA; +++p < 0.0001, KA vs ORV+KA). The number of mice used in each group was 5.