Table 1.
Study Characteristics
| Study | Study Design (N) | Quality | Outcomes |
|---|---|---|---|
| Cilostazol vs usual care | |||
| Beebe, 1999 | RCT (418) | Good | MWD, PFWD, quality of life, safety, mortality, amputation |
| Hobbs, 2007 | RCT (38) | Good | ACD, ICD, safety |
| Strandness, 2002 | RCT (393) | Fair | MWD, safety, mortality |
| Cilostazol vs placebo | |||
| Dawson, 1998 | RCT (77) | Good | ACD, ICD, safety |
| Money, 1998 | RCT (212) | Fair | ACD, ICD, quality of life, safety, mortality |
| Hiatt, 2008; Stone, 2008 | RCT (1435) | Good | Mortality, safety |
| Soga, 2009 | RCT (78) | Good | Mortality, safety, amputation |
| Cilostazol vs pentoxifylline vs placebo | |||
| Dawson, 2000 | RCT (699) | Fair | MWD, PFWD, safety |
| Exercise vs usual care | |||
| Bronas, 2011 | RCT (41) | Good | MWD, PFWD |
| Crowther, 2008 | RCT (21) | Fair | PFWT |
| Gardner, 2002 | RCT (61) | Fair | ACD, ICD, mortality, quality of life, safety, amputation |
| Gardner, 2011 | RCT (119) | Good | PWT, COT, quality of life |
| Gelin, 2001 | RCT (264) | Fair | MWD, mortality, amputation, quality of life |
| Gibellini, 2000 | RCT (40) | Fair | ACD, ICD |
| Hobbs, 2006 | RCT (23) | Fair | ACD, ICD, safety |
| Hobbs, 2007 | RCT (38) | Good | ACD, ICD, safety |
| Tsai, 2002 | RCT (53) | Poor | PWT, COT, quality of life |
| Exercise vs endovascular | |||
| Greenhalgh, 2008 | RCT (127) | Fair | MWD, ICD, mortality, safety, quality of life |
| Kruidenier, 2011 | RCT (70) | Good | ACD, quality of life |
| Mazari, 2012 | RCT (178) | Good | MWD, ICD, quality of life, safety |
| Perkins, 1996 | RCT (56) | Fair | MWD, mortality, safety |
| Gelin, 2001 | RCT (264) | Fair | MWD, mortality, amputation, quality of life |
| Spronk, 2009 | RCT (150) | Fair | MWD, PFWD, mortality, quality of life, safety |
| Hobbs, 2006 | RCT (23) | Fair | ACD, ICD, safety |
| Nordanstig, 2011 | RCT (200) | Good | MWD, mortality, quality of life, amputation |
| Endovascular vs usual care | |||
| Gelin, 2001 | RCT (264) | Fair | MWD, mortality, quality of life, amputation |
| Hobbs, 2006 | RCT (23) | Fair | ACD, ICD, safety |
| Nylaende, 2007 | RCT (56) | Good | MWD, PFWD, mortality, quality of life |
| Whyman, 1997 | RCT (62) | Fair | ICD, MWD |
| Endovascular vs usual care vs exercise | |||
| Murphy, 2012 | RCT (111) | Good | PWT, COT, quality of life, safety |
| Endovascular vs exercise | |||
| Greenhalgh, 2008 | RCT (127) | Fair | ICD, MWD, quality of life, mortality, safety |
| Hobbs, 2006 | RCT (23) | Fair | ACD, ICD, safety |
| Nordanstig, 2011 | RCT (200) | Good | MWD, mortality, quality of life, amputation |
| Kruidenier, 2011 | RCT (70) | Good | ACD, quality of life |
| Mazari, 2012 | RCT (178) | Good | MWD, ICD, quality of life, safety |
| Gelin, 2001 | RCT (264) | Fair | MWD, mortality, amputation, quality of life |
| Perkins, 1996 | RCT (56) | Fair | MWD, mortality, safety |
| Spronk, 2009 | RCT (150) | Fair | MWD, PFWD, mortality, quality of life, safety |
Abbreviations: ACD, absolute claudication distance; COT, claudication onset time; ICD, initial claudication distance; MWD, maximal walking distance; MWT, maximal walking time; N, number of patients; PFWD, pain‐free walking distance; PWT, peak walking time; RCT, randomized controlled trial; TWD, total walking distance.