Table 1.

Established and Experimental/Investigational Scintigraphic Cardiovascular Imaging Techniques

Indication	Technique	Radiotracers	Current Status
Established nuclear imaging techniques
Myocardial perfusion imaging	SPECT	Tl‐201	Less commonly used
		99mTc‐sestamibi (Cardiolite)	In extensive clinical use
		99mTc‐tetrofosmin (Myoview)	In extensive clinical use
	PET	82Rb	In frequent clinical use
		13N ammonia, 15O‐water	Rarely used
		18F‐flupiridaz	Investigational, not FDA approved
Cardiac adrenergic neuronal imaging	SPECT	123I‐MIBG	Only recently FDA approved
Myocardial necrosis imaging	SPECT	111In‐antimyosin	Not in clinical use anymore
Experimental/investigational nuclear imaging techniques
Myocardial apoptosis imaging	SPECT	99mTc‐Annexin	Investigational, not FDA approved
Myocardial necrosis imaging	SPECT	99mTc‐glucarate	Investigational, not FDA approved
Fatty acid metabolism imaging	SPECT	123I‐BMIPP	Investigational, not FDA approved
Glucose metabolism/imaging, myocardial ischemia imaging	PET	18FDG	Investigational
Vascular calcification imaging	PET	18F‐NaF	Investigational, not FDA approved
Hypoxia imaging	PET	18F‐fluoromisonidazole	Investigational, not FDA approved

Abbreviations: ¹⁸FDG, ¹⁸F‐fluorodeoxyglucose; ^99mTc, technetium‐99 m; ¹²³I‐BMIPP, ¹²³I‐labeled β‐methyl iodophenyl pentadecanoic acid; FDA, Food and Drug Administration; PET, positron‐emission tomography; SPECT, single‐photon emission computed tomography.