Table 3.

Association of miR-193a, WT1, and PODXL expressions with renal survival of IMN patients.

Items	Univariate analysis			Multivariate analysis
	Hazard ratio	95% CI	p value	Hazard ratio	95% CI	p value
miR-193a expression*
High (>4.91) vs. Low (≤4.91)	2.05	1.31–3.22	.002	1.91	1.17–3.11	.010
WT1 expression@
High (>1.41) vs. Low (≤1.41)	0.44	0.28–0.69	<.001	0.49	0.30–0.81	.005
PODXL expression#
High (>5.03) vs. Low (≤5.03)	0.44	0.28–0.68	<.001	0.47	0.28–0.76	.002
Age (years old)
>48.21 vs. ≤48.21	1.37	0.88–2.13	.168	1.46	0.90–2.37	.129
Gender
Female vs. Male	0.97	0.63–1.49	.885	0.88	0.55–1.42	.605
Proteinuria (g/24 h)
>3.79 vs. ≤3.79	2.24	1.43–3.53	<.001	1.77	1.09–2.88	.022
Serum Albumin (g/L)
>29.75 vs. ≤29.75	0.78	0.51–1.19	.244	0.78	0.49–1.26	.312
BUN (mmol/L)
>6.43 vs. ≤6.43	0.90	0.59–1.38	.639	1.00	0.62–1.60	.987
GFR (mL/min/1.73 m2)
>68.13 vs. ≤68.13	0.40	0.24–0.61	<.001	0.55	0.34–0.88	.014
Total cholesterol (mmol/L)
>9.29 vs. ≤9.29	1.05	0.68–1.60	.836	1.23	0.77–1.97	.395
Tryglyeride (mmol/L)
>1.87 vs. ≤1.87	0.90	0.59–1.39	.645	1.06	0.66–1.70	.819
Scr (μmol/L)
>174.63 vs. ≤174.63	2.07	1.35–3.18	.001	1.51	0.94–2.42	.087

IMN: Idiopathic membranous nephropathy; BUN: blood urea nitrogen; GFR: glomerular filtration rate; CI: confidence interval; Scr: serum creatinine.

*The whole IMN cohort (n = 364) were divided into highly expressed miR-193a group (>mean miR-193a expression) and lowly expressed miR-193a group (≤mean miR-193a expression).

@The collected 364 IMN patients were categorized into highly expressed WT1 group (>mean WT1 expression) and lowly expressed WT1 group (≤mean WT1 expression).

#The identical IMN cohort (n = 364) were grouped into ones with highly expressed PODXL (>mean PODXL expression) and ones with lowly expressed PODXL (≤mean PODXL expression).